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Innovative Medicine

Basic Research and Development

by Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto

Innovative Medicine

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Book Description

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of "proof of concept". There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

This open book is licensed under a Creative Commons License (CC BY-NC). You can download Innovative Medicine ebook for free in PDF format (15.5 MB).

Table of Contents

Part I
Basic Research for Innovative Medicine
Diverting Glycolysis to Combat Oxidative Stress
Metabolic Regulation by Nuclear Receptors
Fighting Fire with Fire in Cancer
Linear Polyubiquitination: A Crucial Regulator of NF-κB Activation
VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders
Roles of E-cadherin in Hepatocarcinogenesis
The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
Inhibitory Immunoreceptors on Mast Cells in Allergy and Infl ammation
Doxycycline-Inducible Autoimmune Blistering Skin Disease Model
T Cell Senescence and Autoimmunity
Part II
Translational Research for Innovative Medicine
IL-6: A New Era for the Treatment of Autoimmune Infl ammatory Diseases
Tadamitsu Kishimoto , Sujin Kang , and Toshio Tanaka Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies
Multifaceted Translational Approach to Major Mental Illness
Translational Research of Leptin in Lipodystrophy and Its Related Diseases
Translational Research of the Activation of the C-Type Natriuretic Peptide (CNP)-Guanylyl Cyclase-B Pathway for Skeletal Dysplasia
Clarity and Challenges in Tissue Fibrosis
TRP Channels: Their Function and Potentiality as Drug Targets
Autophagic Cell Death and Cancer Chemotherapeutics
Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis
RNA Activation
Part III
New Technology for Innovative Medicine
Proceedings of the Uehara Memorial Foundation. Innovative Medicine: Basic Research and Development. Cardiac Reprogramming for Heart Repair
Development of a New In Vivo Optical Probe for Biological Diagnosis and Therapy
Introduction of Mesenchymal Stem Cells for Liver Surgery (Hepatectomy and Transplantation)
Synaptic and Axonal Plasticity Induction in the Human Cerebral Cortex
TIM-3 Is a Novel Therapeutic Target for Eradicating Acute Myelogenous Leukemia Stem Cells
TGF-β LAP Degradation Products, a Novel Biomarker and Promising Therapeutic Target for Liver Fibrogenesis
Cell-Based Regenerative Therapy for Liver Disease

Book Details

Innovative Medicine
ISBN13 Digital
ISBN10 Digital
PDF Size
15.5 MB

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