Innovative Medicine

Basic Research and Development

by Kazuwa Nakao, Nagahiro Minato, Shinji Uemoto

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Book Description

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of "proof of concept". There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

This open book is licensed under a Creative Commons License (CC BY-NC). You can download Innovative Medicine ebook for free in PDF format (15.5 MB).

Table of Contents

Part I
Basic Research for Innovative Medicine
 
 
Diverting Glycolysis to Combat Oxidative Stress
3
 
Metabolic Regulation by Nuclear Receptors
25
 
Fighting Fire with Fire in Cancer
39
 
Linear Polyubiquitination: A Crucial Regulator of NF-κB Activation
51
 
VCP, a Major ATPase in the Cells, as a Novel Drug Target for Currently Incurable Disorders
61
 
Roles of E-cadherin in Hepatocarcinogenesis
71
 
The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors
79
 
Inhibitory Immunoreceptors on Mast Cells in Allergy and Infl ammation
95
 
Doxycycline-Inducible Autoimmune Blistering Skin Disease Model
109
 
T Cell Senescence and Autoimmunity
119
Part II
Translational Research for Innovative Medicine
 
 
IL-6: A New Era for the Treatment of Autoimmune Infl ammatory Diseases
131
 
Tadamitsu Kishimoto , Sujin Kang , and Toshio Tanaka Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies
149
 
Multifaceted Translational Approach to Major Mental Illness
157
 
Translational Research of Leptin in Lipodystrophy and Its Related Diseases
165
 
Translational Research of the Activation of the C-Type Natriuretic Peptide (CNP)-Guanylyl Cyclase-B Pathway for Skeletal Dysplasia
177
 
Clarity and Challenges in Tissue Fibrosis
187
 
TRP Channels: Their Function and Potentiality as Drug Targets
195
 
Autophagic Cell Death and Cancer Chemotherapeutics
219
 
Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis
227
 
RNA Activation
241
Part III
New Technology for Innovative Medicine
 
 
Proceedings of the Uehara Memorial Foundation. Innovative Medicine: Basic Research and Development. Cardiac Reprogramming for Heart Repair
253
 
Development of a New In Vivo Optical Probe for Biological Diagnosis and Therapy
265
 
Introduction of Mesenchymal Stem Cells for Liver Surgery (Hepatectomy and Transplantation)
281
 
Synaptic and Axonal Plasticity Induction in the Human Cerebral Cortex
295
 
TIM-3 Is a Novel Therapeutic Target for Eradicating Acute Myelogenous Leukemia Stem Cells
307
 
TGF-β LAP Degradation Products, a Novel Biomarker and Promising Therapeutic Target for Liver Fibrogenesis
317
 
Cell-Based Regenerative Therapy for Liver Disease
327

Book Details

Subject
Medical
Publisher
Springer
Published
2015
Pages
339
Edition
1
Language
English
ISBN13
9784431556503
ISBN10
4431556508
ISBN13 Digital
9784431556510
ISBN10 Digital
4431556516
PDF Size
15.5 MB
License
CC BY-NC

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