Evaluating Evidence of Mechanisms in Medicine

Principles and Procedures

by Veli-Pekka Parkkinen, Christian Wallmann, Michael Wilde, Brendan Clarke, Phyllis Illari, Michael Kelly, Charles Norell, Federica Russo, Beth Shaw, Jon Williamson

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Book Description

This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.

This open book is licensed under a Creative Commons License (CC BY). You can download Evaluating Evidence of Mechanisms in Medicine ebook for free in PDF format (4.5 MB).

Book Details

Subject
Philosophy
Publisher
Springer
Published
2018
Pages
131
Edition
1
Language
English
ISBN13
9783319946092
ISBN10
3319946099
ISBN13 Digital
9783319946108
ISBN10 Digital
3319946102
PDF Size
4.5 MB
License
CC BY

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