This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for evaluating evidence of mechanisms, and for combining this evaluation with evidence of association in order to yield an overall assessment of effectiveness. Evidence-based medicine seeks to achieve improved health outcomes by making evidence explicit and by developing explicit methods for evaluating it. To date, evidence-based medicine has largely focused on evidence of association produced by clinical studies. As such, it has tended to overlook evidence of pathophysiological mechanisms and evidence of the mechanisms of action of interventions. The book offers a useful guide for all those whose work involves evaluating evidence in the health sciences, including those who need to determine the effectiveness of health interventions and those who need to ascertain the effects of environmental exposures.
This open book is licensed under a Creative Commons License (CC BY). You can download Evaluating Evidence of Mechanisms in Medicine ebook for free in PDF format (4.5 MB).
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clini...
The 2nd edition of Evidence-Based Practice in Clinical Social Work continues to bridge the gap between social work research and clinical practice, presenting EBP as both an effective approach to social work and a broader social movement. Building on the models and insights outlined in the first edition, this new edition provides updated research an...
This open volume identifies the common and specific aspects of social mechanisms that generate inequalities, through comparative analyses of different dimensions in which inequalities are expressed. It includes studies on social inequalities in 5 European and 5 Latin American countries, along 11 thematic axes: inequalities in the labour market and ...
It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot ...
This open access volume provides evidence-based knowledge on European solidarity and citizen responses in times of crisis. Does the crisis of European integration translate into a crisis of European solidarity, and if yes, what are the manifestations at the level of individual citizens? How strongly is solidarity rooted at the individual level, bot...
This book maps the youth transitions of descendants of migrants from Turkey living in Amsterdam and Strasbourg, through a comparative mixed-methods research design. As such, it is of interest to discussions in youth sociology, social mobility and second-generation research. The book follows transition trajectories of the second-generation, from sch...