This book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
This open book is licensed under a Creative Commons License (CC BY). You can download Nicotinic Acetylcholine Receptor Signaling in Neuroprotection ebook for free in PDF format (5.1 MB).
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clini...
This book constitutes the thoroughly refereed proceedings of the 9th International Conference on Intelligent Human Computer Interaction, IHCI 2017, held in Evry, France, in December 2017.
The 15 papers presented together with three invited papers were carefully reviewed and selected from 25 submissions. The conference is forum for the presentation...
This open access volume explores how UN peace operations are adapting to four trends in the changing global order: (1) the rebalancing of relations between states of the global North and the global South; (2) the rise of regional organisations as providers of peace; (3) the rise of violent extremism and fundamentalist non-state actors; and (4) incr...
First IFIP International Cross-Domain Conference, IFIPIoT 2018, Held at the 24th IFIP World Computer Congress, WCC 2018, Poznan, Poland, September 18-19, 2018, Revised Selected Papers...
This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews re...
This open access volume provides evidence-based knowledge on European solidarity and citizen responses in times of crisis. Does the crisis of European integration translate into a crisis of European solidarity, and if yes, what are the manifestations at the level of individual citizens? How strongly is solidarity rooted at the individual level, bot...