Self-Assembled Molecules – New Kind of Protein Ligands

Supramolecular Ligands

by Irena Roterman, Leszek Konieczny

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Book Description

The subject of this book relates to protein ligands with particular structural and complexation properties. They are composed of self-assembled molecules, capable of penetrating as a unit into proteins outside the binding site. The ribbon-like supramolecular system only permits the penetration of self-assembled molecules into the protein-body and formation of stable complexes. Supramolecular Congo red and similar compounds fit these requirements. Destabilized protein fragments enable the penetration of such ligands, with susceptibility to supramolecular ligand binding often associated with protein function. As a result, complexation modifies their functional effects. The activity of enzymes is inhibited by arresting them in the complexed state, but "naturally irreversible" complexation as in the case of immune complexation, is enhanced instead. This property offers many attractive possibilities of using supramolecular ligands as described in this book.

This open book is licensed under a Creative Commons License (CC BY). You can download Self-Assembled Molecules – New Kind of Protein Ligands ebook for free in PDF format (8.4 MB).

Book Details

Subject
Medical
Publisher
Springer
Published
2018
Pages
145
Edition
1
Language
English
ISBN13
9783319656380
ISBN10
3319656384
ISBN13 Digital
9783319656397
ISBN10 Digital
3319656392
PDF Size
8.4 MB
License
CC BY

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