Evaluating Evidence of Mechanisms in Medicine
This book is the first to develop explicit methods for evaluating evidence of mechanisms in the field of medicine. It explains why it can be important to make this evidence explicit, and describes how to take such evidence into account in the evidence appraisal process. In addition, it develops procedures for seeking evidence of mechanisms, for eva...
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
This free book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a r...
ENZYMES: Catalysis, Kinetics and Mechanisms
This enzymology textbook for graduate and advanced undergraduate students covers the syllabi of most universities where this subject is regularly taught. It focuses on the synchrony between the two broad mechanistic facets of enzymology: the chemical and the kinetic, and also highlights the synergy between enzyme structure and mechanism. Designed f...
Loss and Damage from Climate Change
This book provides an authoritative insight on the Loss and Damage discourse by highlighting state-of-the-art research and policy linked to this discourse and articulating its multiple concepts, principles and methods. Written by leading researchers and practitioners, it identifies practical and evidence-based policy options to inform the discourse...
Diversity and Evolution of Butterfly Wing Patterns
This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as "evo-devo,&quo...
Sexual Reproduction in Animals and Plants
This book contains the proceedings of the International Symposium on the Mechanisms of Sexual Reproduction in Animals and Plants, where many plant and animal reproductive biologists gathered to discuss their recent progress in investigating the shared mechanisms and factors involved in sexual reproduction. This now is the first book that reviews re...
The Pangenome
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study ...
Robotics
This book introduces readers to robotics, industrial robot mechanisms, and types of robots, e.g. parallel robots, mobile robots and humanoid robots. The book is based on over 20 years of teaching robotics and has been extensively class tested and praised for its simplicity.It addresses the following subjects: a general introduction to robotics; bas...
Manifesto of the New Economy
How do social networking services earn money?What is the "second hand of the market" and how does it operate? Why does society need so many different kinds of goods? What does happiness economics not reveal about happiness?What is the link between talent, success and "stardom"? What is the business development model for the ent...
Innovative Medicine
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clini...
Ocean-Atmosphere Interactions of Gases and Particles
The oceans and atmosphere interact through various processes, including the transfer of momentum, heat, gases and particles. In this book leading international experts come together to provide a state-of-the-art account of these exchanges and their role in the Earth-system, with particular focus on gases and particles. Chapters in the book cover: ...
Fulfilling the Promise of Technology Transfer
Universities and research institutes are increasingly expected to contribute to society by creating innovation from the returns of their research results and the establishment of new technologies. Toward that goal, Keio University in Japan held an international symposium titled "Fulfilling the Promise of Technology Transfer: Fostering Innovati...
Accountability in Public Policy Partnerships
A PDF version of this book is available for free in open access via the OAPEN Library platform, www.oapen.org. This book presents a new model of accountability which ensures that public-private partnerships don't erode public accountability. It defines concrete accountability standards for different types of partnerships....
A Time for Metabolism and Hormones
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspe...
From Bilateral Arbitral Tribunals and Investment Courts to a Multilateral Investment Court
This book considers the potential setup for a future Multilateral Investment Court (MIC). The option of an MIC was first discussed by the EU Commission in 2016 and has since been made an official element of the EU Common Commercial Policy. In 2017, UNCITRAL also decided to discuss the possibility of an MIC, and on 20 March 2018, the Council of the ...
Sustainable Living with Environmental Risks
We are not free from environmental risks that accompany the development of human societies. Modern economic development has accelerated environmental pollution, caused loss of natural habitats, and modified landscapes. These environmental changes have impacted natural systems: water and heat circulation, nutrient cycling, and biodiversity. These ch...
Youth Transitions among Descendants of Turkish Immigrants in Amsterdam and Strasbourg:
This book maps the youth transitions of descendants of migrants from Turkey living in Amsterdam and Strasbourg, through a comparative mixed-methods research design. As such, it is of interest to discussions in youth sociology, social mobility and second-generation research. The book follows transition trajectories of the second-generation, from sch...
The Biopsychosocial Model of Health and Disease
'This is an incredibly audacious book. Derek Bolton and Grant Gillett brilliantly succeed in providing the big picture that was lacking in the defense of the biopsychosocial model promoted by Engel 40 years ago.' - Steeves Demazeux, Assistant Professor in philosophy, Bordeaux-Montaigne University, FranceThis book is a systematic update of the philo...
Delusions in Context
'This is an excellent and engaging resource on delusions. The idea that delusions should not be seen as radically different from other beliefs… is an important challenge to much contemporary thinking and practice. It should be of interest to anyone studying delusional beliefs, and to all those who aim to help people who are troubled by them.'Phil...
Make Life Visible
This book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecula...
Security in Computer and Information Sciences
This book constitutes the thoroughly refereed proceedings of the First International ISCIS Security Workshop 2018, Euro-CYBERSEC 2018, held in London, UK, in February 2018.The 12 full papers presented together with an overview paper were carefully reviewed and selected from 31 submissions. Security of distributed interconnected systems, software sy...
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide...
Exploring Resilience
Resilience has become an important topic on the safety research agenda and in organizational practice. Most empirical work on resilience has been descriptive, identifying characteristics of work and organizing activity which allow organizations to cope with unexpected situations. Fewer studies have developed testable models and theories that can be...
The Governing-Evaluation-Knowledge Nexus
This book analyses the interplay between governing, evaluation and knowledge with an empirical focus on Swedish higher education. It investigates the origins, logics, and mechanisms of evaluation and quality assurance reforms and their dynamic interactions with institutional, national and European policy contexts. The chapters report findings from ...
Etiology and Morphogenesis of Congenital Heart Disease
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are i...
Freshwater Governance for the 21st Century
The objective of this book is to broadly illustrate the key aspects of water governance, mapping the spectrum of decision-making from techno-centric and eco-centric approaches, to hybrid concepts and people-centric approaches. Topics covered include the challenges for water-governance models, the polycentric model, the integration challenge, water ...
The InfoSec Handbook
The InfoSec Handbook offers the reader an organized layout of information that is easily read and understood. Allowing beginners to enter the field and understand the key concepts and ideas, while still keeping the experienced readers updated on topics and concepts. It is intended mainly for beginners to the field of information security, writte...
Pre-Field Screening Protocols for Heat-Tolerant Mutants in Rice
This book presents simple, robust pre-field screening protocols that allow plant breeders to screen for enhanced tolerance to heat stress in rice. Two critical heat-sensitive stages in the lifecycle of the rice crop are targeted – the seedling and flowering stages – with screening based on simple phenotypic responses. The protocols are based on...
Snow Sports Trauma and Safety
This book covers the latest in snow sport epidemiology, snow sport injuries and treatment, and biomechanical/mechanical engineering related to snow sports injuries (mechanisms of injury, injury prevention by equipment design, injury prevention by design of resort features, and more). It brings together a collection of papers from the International ...
Dynamics of Long-Life Assets
The editors present essential methods and tools to support a holistic approach to the challenge of system upgrades and innovation in the context of high-value products and services. The approach presented here is based on three main pillars: an adaptation mechanism based on a broad understanding of system dependencies; efficient use of system knowl...
Protest Movements in Asylum and Deportation
This book deals with contestations "from below" of legal policies and implementation practices in asylum and deportation. Consequently, it covers three types of mobilization: solidarity protests against the deportation of refused asylum seekers, refugee activism campaigning for residence rights and inclusion, and restrictive protests agai...
Socioeconomics of Agriculture
This book applies for the first time emerging concepts of socioeconomics to analyse an economic sector, namely agriculture. It considers the rational choices of all actors in the system (just as agricultural economists do) and their cultural preferences and constraints (just as rural sociologists do). Socioeconomic concepts are subsequently used to...

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