Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide...
Grey Area
Coffeeshops are the most famous example of Dutch tolerance. But in fact, these cannabis distributors are highly regulated. Coffeeshops are permitted to break the law, but not the rules. On the premises, there cannot be minors, hard drugs or more than 500 grams. Nor can a coffeeshop advertise, cause nuisance or sell over five grams to a person in a ...
Non-Vitamin K Antagonist Oral Anticoagulants
This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, an...
Innovative Medicine
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clini...
Primary Angioplasty
This quick-reference handbook offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now...
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
This work is devoted to understanding the recent advances in nuclear medicine and molecular imaging technologies along with their application to integrated medical therapy and future drug development. This anthology is based on the international symposium in 2015 entitled "Perspective on Nuclear Medicine for Molecular Diagnosis and Integrated ...
Tuberculosis in Adults and Children
This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resour...
Pharmacovigilance in the European Union
The book presents the results of an in-depth comparative study assessing the implementation of the EU Pharmacovigilance Directive in six EU Member States. By going beyond legal transposition and instead focusing on practical implementation, this study aims to close a gap in EU compliance research. Based on qualitative interviews with relevant actor...
Infection Control in the Dental Office
This book reviews the principles of infection control and the guidelines and standards of care in multiple countries, discussing them within the context of the practice of dentistry. The aim is to enable dental practitioners to ensure that the appropriate measures are adopted for each patient contact, thereby minimizing the risk of transmission of ...
Applied Bioinformatics
This book introduces readers to the basic principles of bioinformatics and the practical application and utilization of computational tools, without assuming any prior background in programming or informatics. It provides a coherent overview of the complex field and focuses on the implementation of online tools, genome databases and software that c...
Foundations of Behavioral Health
This comprehensive book examines the organization, financing, delivery, and outcomes of behavioral health (i.e., alcohol, drug abuse, and mental health) services from both U.S. and global perspectives. Addressing the need for more integrative and collaborative approaches in public health and behavioral health initiatives, the book covers the fundam...
Making Medicines in Africa
The importance of the pharmaceutical industry in Sub-Saharan Africa, its claim to policy priority, is rooted in the vast unmet health needs of the sub-continent. Making Medicines in Africa is a collective endeavour, by a group of contributors with a strong African and more broadly Southern presence, to find ways to link technological development, i...
The Codes of the Street in Risky Neighborhoods
This book presents a comparative look at the norms and attitudes related to youth violence. It aims to present a perspective outside of the typical Western context, through case studies comparing a developed / Western democracy (Germany), a country with a history of institutionalized violence (South Africa), and an emerging democracy that has exper...
Alternatives to Animal Testing
This book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as th...
High-Performance Modelling and Simulation for Big Data Applications
This book is the final compendium of case studies emanated from the 4-year COST Action IC1406 "High-Performance Modelling and Simulation for Big Data Applications" (cHiPSet). Funded by the European Commission from 2015, cHiPSet has created a sustainable reference network linking applied research in High Performance Computing (HPC) and Mod...
Information Infrastructures within European Health Care
This book consolidates experiences from across Europe on the design, development, implementation and evolution of inter-organisational information infrastructures for healthcare. It provides insights with practical relevance for those involved or interested in the planning and implementation of such infrastructures and includes 11 empirical cases o...
Public Health Ethics: Cases Spanning the Globe
This book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively...
Animals and the Shaping of Modern Medicine
This book breaks new ground by situating animals and their diseases at the very heart of modern medicine. In demonstrating their historical significance as subjects and shapers of medicine, it offers important insights into past animal lives, and reveals that what we think of as 'human' medicine was in fact deeply zoological.Each chapter analyses a...
Clinical Text Mining
This book describes the results of natural language processing and machine learning methods applied to clinical text from electronic patient records.It is divided into twelve chapters. Chapters 1-4 discuss the history and background of the original paper-based patient records, their purpose, and how they are written and structured. These initial ch...
A History of Male Psychological Disorders in Britain, 1945–1980
This book explores the under-researched history of male mental illness from the mid-twentieth century. It argues that statistics suggesting women have been more vulnerable to depression and anxiety are misleading since they underplay a host of alternative presentations of 'distress' more common in men....
Fungal Disease in Britain and the United States 1850–2000
The narrative of 20th-century medicine is the conquering of acute infectious diseases and the rise in chronic, degenerative diseases. The history of fungal infections does not fit this picture. This book charts the path of fungal infections from the mid 19th century to the dawn of the 21st century....
Advances in Pharma Business Management and Research
This free book presents a unique collection of practical examples from the field of pharma business management and research. It covers a wide range of topics such as: 'Brexit and its Impact on pharmaceutical Law - Implications for Global Pharma Companies', 'Implementation of Measures and Sustainable Actions to Improve Employee's Engagement', 'Globa...
Innovation, Economic Development, and Intellectual Property in India and China
This book analyses intellectual property and innovation governance in the development of six key industries in India and China. These industries are reflective of the innovation and economic development of the two economies, or of vital importance to them: the IT Industry, the film industry, the pharmaceutical industry, plant varieties and food sec...
Good Research Practice in Non-Clinical Pharmacology and Biomedicine
This free book provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine....
Introduction to the American Criminal Justice System
This open book is unique because it was a collaborative effort by all Criminology and Criminal Justice professors at Southern Oregon University (SOU) in Ashland, Oregon. This book can be used on a quarter or semester system, as well as cover topics that may get left out of some introductory texts such as controversial issues in the criminal justice...
Clinical Methods in Medical Family Therapy
This landmark text describes research-informed practices and applications of Medical Family Therapy (MedFT) across an array of care environments and clinical populations. It is a timely release for a rapidly growing field and ably contextualizes MedFT within a myriad of areas, including family medicine, obstetrics and gynecology, psychiatry, alcoho...
Prevention and Control of Infections in Hospitals
This volume offers extensive information on preventive and infection surveillance procedures, routines and policies adapted to the optimal infection control level needed to tackle today's microbes in hospital practice. It especially focuses on preventive measures for serious hospital infections. Each chapter includes a practical section that addres...
Coronavirus Disease 2019 (COVID-19)
This book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID-19). Discussing various aspects of COVID-19 infection, including global epidemiology, genome organization, immunopathogenesis, transmissio...
Criminal Justice and Mental Health
This textbook provides an overview for students in Criminology and Criminal Justice about the overlap between the criminal justice system and mental health. It provides an accessible overview of basic signs and symptoms of major mental illnesses and size of scope of justice-involved individuals with mental illness.In the United States, the cri...
Communication and Bioethics at the End of Life
This casebook provides a set of cases that reveal the current complexity of medical decision-making, ethical reasoning, and communication at the end of life for hospitalized patients and those who care for and about them. End-of-life issues are a controversial part of medical practice and of everyday life. Working through these cases illuminates bo...
Perspectives on Elderly Crime and Victimization
This textbook focuses on the criminality and victimization of the elderly population. It provides a global perspective on the extent of elderly crime and victimization, with international comparisons for addressing the problem. It explores the extent and types of crimes committed by the elderly, the characteristics of older criminals, and the respo...